It's clear that the characters of Azumanga Daioh have their traits that make them unique in their own way. However...

What would be your reaction if you met a person who was exactly like one of these characters?

I think everyone has, at some point in their lives, known someone like Osaka and Tomo. My reaction was to laugh and stay out of their way, respectively.

I would feed them peanuts! =o

...or am I thinking of elephants? I always get those confused.

I once saw a dog which was the same breed as Mr Tadakichi, whenever I saw him after all I could think of was Mr Tadakichi.

Er...that's all I have to say really XD

I'd be all like "Woah....." but I wouldn't make a big deal of it.